beREADY - endometrial receptivity test
beREADY test ensures that the embryo is transferred at the optimal time.
beREADY test increases the chance of getting pregnant and saves your embryos, time and money.
beREADY test is suitable for all patients who are looking for the best IVF treatment.
Benefits of endometrial receptivity test
Please note that 72.5% pregnancy rate was achieved by the first IVF cycle when endometrial receptivity test was used.*
Fourfold live birth rate increase acheived among RIF patients after endometrial receptivity testing.**
56.7% of patients with recurrent implantation failure became pregnant after using the beREADY test. ***
Did you know that 1 out of 3 patients experience IVF failure because the embryo is transferred too early or too late?****
Genetics and the endometrium - how do they work?
Genes make us different, and IVF treatment is no exception. About 30% of women have displaced Window Of Implantation (WOI) compare to average. These patients need a personalized plan because the "average" does not work for all.
Your endometrial readiness is affected by your genes and its mediated individual drug response. It means that drug response influence your endometrial readiness and implantation rate after embryo transfer.
The study showed that a personalized IVF treatment plan increased cumulative pregnancy rate up to 94%*. That is why you deserve advanced medicine and higher success rates.
What does the beREADY test show?
The test analyzes endometrial maturity. Thanks to the information obtained, it is possible to transfer the embryo at the optimal time.
The test results will reveal whether your endometrium was receptive enough for embryo implantation at the time of collection or whether it is necessary to adjust the optimal time for sooner or later.
PRE or EARLY-RECEPTIVE
Your endometrium needs more time! The implantation window has shifted and embryo transfer should be performed later. The resulting report indicates the exact timing that is optimal for you.
FULLY-RECEPTIVE
The test confirms that you have an expected window of implantation and there is no need to change the timing.
RECEPTIVE
You have rapid endometrial maturation! The implantation window has shifted and embryo transfer should be performed earlier. The final report indicates the exact timing that is optimal for you.
How does the beREADY test work?
Results are available in 1-2 weeks
Comparison of endometrial receptivity tests
The beREADY test is developed based on carefully classified samples and independent clinical validation.
As a comparison, 45 HRT patients’ samples were involved in a comparison against the Endometrial Receptivity Analysis (ERA, Igenomix) test. The concordance rate between the two tests is as high as 96% because the same tissue samples were analyzed.
The beREADY test applies novel and highly accurate TAC-seq DNA sequencing technology. The technology enables the detection of biomarker molecules at a single-molecule level and provides ultimate sensitivity.
Referred publications and research behind beREADY test
* Simón et al., A 5-year Multicenter Randomized Controlled Trial of In Vitro Fertilization with Personalized Blastocyst Transfer versus Frozen or Fresh Transfer. 2020, Reproductive BioMedicine Online, PubMed ID 32723696. Link to original study.
** Haouzi et al., Customized Frozen Embryo Transfer after Identification of the Receptivity Window with a Transcriptomic Approach Improves the Implantation and Live Birth Rates in Patients with Repeated Implantation Failure. 2021, Reproductive Sciences, PubMed ID 32725589. Link to original study.
*** Teder et al., TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting. 2018, npj Genomic Medicine, PubMed ID 30588329. Link to original study.
**** Ruiz-Alonso et al., The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. 2013, Fertility and Sterility, PubMed ID 23756099. Link to original study.
Saare et al., A molecular tool for menstrual cycle phase dating in endometriosis transcriptomic studies. 2019, Biology of Reproduction, PubMed ID 31004479. Link to original study.
Suhorutshenko et al., Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. 2018, Human Reproduction, PubMed ID 30295736. Link to original study.
Altmäe et al., Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. 2018, Scientific Reports, PubMed ID 28855728. Link to original study.
Krjutškov et al., Single-cell transcriptome analysis of endometrial tissue. 2016, Human Reproduction, PubMed ID 26874359.
